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KMID : 0352519970340010035
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Korea Univercity Medical Journal
1997 Volume.34 No. 1 p.35 ~ p.46
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The Usefulness of p21, p53 and PCNA Expression as Prognostic Factors in Papillary Thyroid Cancer
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Abstract
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There were many studies to show that p21, p53 and PCNA overexpression were known to be predictive factors for human cancer. The purpose of this study was to evaluate whether these molecular oncogenes were useful as prognostic factors in patient
with
papillary thyroid carcinoma.
Using the monoclonal antibodies MAb Y13-259, PAb 1801 and PC10 against each oncogene protein studied, the avidin-biotin peroxidase complex method provided immunohistochemical staining of bound oncogene protein for p21-ras, p53 and PCNA,
respectively.
Analysis were made on paraffin-embedded pathology tissues of 58 patients with papillary thyroid cancer who underwent thyroidectomy in Korea University Anam Hospital from January 1984 to December 1992.
Forty-six patients were women (79.3%) and 12 were men (21.7%), with mean age 42.0±19.2 years. Patients were divided into groups based on postoperative tumor recurrence. Eleven patients had recurrence of disease ; 47 remained free of
loco-regional
or
distant metastasis at mean follow-up of 74.3 months (range 36 - 142 months). The positive rates of p21, p53 and PCNA were 22.2% (13 of 56), 45.6% (26 of 57) and 70.9% (39 of 55) respectively. No significant differences were observed in the age
and
sex
of patients with p21, p53 and PCNA positive and negative tumors. Using stastical analysis, there was no significant difference in p21, p53 and PCNA stains between recurrent and non-recurrent groups (p>0.05), while AMES score (p=0.042), the tumor
size
(p=0.005), capsular invasion (p=0.003) and lymph node metastasis (p=0.002) were significantly correlated with tumor recurrence.
Conclusion: This study shows that expression of p21, p53, PCNA are not useful as prognostic factors in papillary thyroid cancer.
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KEYWORD
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